ERN1 and hepatocellular carcinoma: Immunoblotting revealed that IMB-6G treatment increased the phosphorylation levels of IRE1α (Ser724) and PERK (Thr 980) in a concentration- and time-dependent manner in HCC cells (Figure 4A and 4B, upper panel), but did not increase the expression level of cleaved p50ATF6 (Supplementary Figure S3).