EIF2AK3 and hepatocellular carcinoma: Because IMB-6G significantly increased the phosphorylation of PERK (Figure 4) and CHOP expression in HCC cells (Figure 3), meanwhile PERK silencing suppressed IMB-6G-induced HCC cell death and CHOP expression (Figure 5 and Supplementary Figure S4), we next investigated whether CHOP induction is essential for IMB-6G-induced apoptosis.