By comparing our results with previous reports, we observed one nonsense PTPN3 mutation in a case but no additional mutation was found in nine phosphatase genes (PTPN3, PTPRB, PTPRQ, PTPRS, PTPRZ1, SBF1, SBF2, MTMR3, and EYA1) that are known to be frequently mutated in ICC [11], but the prevalence of mutations involving phosphatase as well as the frequent somatic mutations on APC and genes belonging to the TGFβ signaling pathway requires further validation in a larger cohort. The gene discussed is APC; the disease is intrahepatic cholangiocarcinoma.