Aberrant KPNA2 expression has been observed in various human cancers, including non-small cell lung cancer (NSCLC), breast cancer, melanoma, cervical cancer, esophageal cancer, ovarian cancer, prostate cancer, liver cancer, bladder cancer, brain cancer, gastric cancer and upper tract urothelial carcinoma [3-16]. The gene discussed is KPNA2; the disease is cancer.