In addition to its familiar matrix metalloproteinase (MMP)-inducing ability, CD147 plays a vital role in neural network formation and development [31, 32], spermatogenesis and fertilization [33, 34], lymphocyte responsiveness [35], rheumatoid arthritis, HIV infection [36, 37], tumor metastasis, and tumor angiogenesis [11]. This evidence concerns the gene BSG and neoplasm.