The enhancing effects of HAb18G/CD147 on the adhesion, invasion capacities and secretion of MMPs of hepatoma cells (SMMC-7721) were partially blocked by integrin α3β1 and α6β1 antibodies; Wortmannin and LY294002, specific PI3K inhibitors, were able to reverse the attenuating effect of HAb18G/CD147 on the negative regulation of Ca2+ entry by PI3K. The gene discussed is BSG; the disease is hepatocellular carcinoma.