As previously reported, CD147 was highly enriched on the surface of various malignant tumor cells, including cancers of the brain, lung, breast, liver, bladder, and skin [12, 13], triggering the production and release of MMPs in the surrounding stromal fibroblasts and endothelial cells, as well as in the tumor cells themselves, via cGMP/NO-sensitive capacitative calcium entry. Here, BSG is linked to neoplasm.