In addition to evoking different sensitivities to the acidic microenvironment in normal cell competitors and tumor cells, extracellular acidosis also promotes angiogenesis through the enhanced release of VEGF [123, 124] and indirectly accelerated extracellular matrix degradation by inducing adjacent fibroblast and macrophage cells to release proteolytic enzymes such as cathepsin B [125] or by increased lysosomal recycling [126]. The gene discussed is VEGFA; the disease is neoplasm.