In detail, CD147 colocalized and interacted with integrin α3β1 [39] and α6β1 [60] in the invasion and metastasis potential of hepatoma cells via the integrin α3β1-mediated focal adhesion kinase (FAK)-paxillin and FAK-PI3K-Ca2+ signaling pathways, and the integrin α6β1-mediated PI3K-Ca2+ signaling pathways, respectively. This evidence concerns the gene BSG and hepatocellular carcinoma.