Previous findings have indicated that CD147 expression protects breast cancer cells from anoikis, at least in part, by a mitogen-activated protein kinase-dependent reduction of Bim, which is a proapoptotic BH3-only protein, and that knockdown of CD147 expression by RNA interference sensitized cancer cells to anoikis through the activation of caspase-3 [52]. Here, BSG is linked to cancer.