In the same manner, the RGD motif in many extracellular matrix proteins interacted with the MIDAS motif of integrin β1 submit [62]; therefore the RGD motif may have competitively inhibited the CD147−integrin β1 interaction and attenuated the malignant properties of tumor cells induced by CD147, which would be a potentially innovative therapeutic strategy for tumors. This evidence concerns the gene BSG and neoplasm.