BSG and hepatocellular carcinoma: It has been reported that anti-CD147 monoclonal antibody and 131I-labeled HAb18 F(ab’)2 metuximab monoclonal antibody injection (Brand name: Licartin), as a targeted radioimmunotherapy for HCC patients significantly decrease the secretion of MMPs and the invasive potential of HCC cells, which could be used to effectively prevent the recurrence and metastasis of HCC after hepatectomy and liver transplantation [16, 143].