Ke et al. found that CD147 expression was significantly higher in hepatocellular carcinoma cells (SMMC-7721) resistant to anoikis compared with the parental cells, and that CD147 knockdown by siRNA also remarkably induced cell anoikis, partially via inactivation of the PI3K/Akt signaling pathway [53]. The gene discussed is BSG; the disease is hepatocellular carcinoma.