PRSS2 and pancreatitis: A heatmap showed that the expression of ductal cell-related genes (Krt7, Krt8, Krt18, Krt19, and Krt20) was significantly higher and that of acinar cell-related genes (Prss2, Ctrc, Amy2a, and Pla2g1b) was significantly lower in the KrasG12D pancreatitis group, reflecting shifting dynamics from the acinar cell compartment to the ductal-like cell compartment (Figure 2C).