RASSF6 and metastatic melanoma: In further studies, we would like to collect a larger set of sCRC samples for deep sequencing, and if possible, to analyze the promoter methylation of RASSF6. Hypermethylation status of RASSF6 were found in metastatic melanoma, neuroblastoma and across the whole CpG island in leukemia cell lines [9, 11, 14].