2011, Martinez‐Sanchez et al. 2015). The Argonaute 2 (Ago2) component of the RISC complex controls compensatory β‐cell proliferation and is under the control of miR‐184, which is negatively regulated by blood glucose levels, thus providing a systemic feedback to the β‐cells reflecting systemic insulin resistance (Tattikota et al. 2014, 2015). This evidence concerns the gene AGO2 and Insulin resistance.