It is known that the constitutive NF-κB activation in ABC-DLBCL is caused by individual or overlapping known mutations like MYD88 L265P, CARD11, TNFAIP3 and CD79B/A [16], which are involved in antigen-specific B-cell receptor (BCR) and Toll-like receptor (TLR) induced NF-κB activation. This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.