Specifically, the expression of NF-κB, p-p65 and p52 was predicted to be a poor prognosis factor of DLBCL in some studies [42, 43], as well as the p-IΚBα in ABC-DLBCL [44], but the expression of Rel was reported to be associated with superior clinical outcome [45]. This evidence concerns the gene REL and diffuse large B-cell lymphoma.