Indeed, deregulation of CDK2 and CDK4 genes has been found to be associated with the transformation process of the transformed DLBCL [56], additionally, CDKN2A deletion was predicted for poor prognosis in DLBCL [57], suggesting the important role of CDK2 in pathogenesis of DLBCL. This evidence concerns the gene CDK4 and diffuse large B-cell lymphoma.