Since lenalidomide was reported to exert its immunomodulatory function through PI3K/Akt pathway in CLL [11], we found that lenalidomide only slightly dephosphorylated p-Akt (Ser 473) in OCI-Ly10 and p-Akt (Thr 308) in Su-DHL2, which in line with the study of lenalidomide cytotoxicity in MCL [41]. The gene discussed is AKT1; the disease is mantle cell lymphoma.