In 2001, Anja Muller first proposed that the process of tumour cell migration to target organs, including lymphatic vessels and lymph nodes, may be similar to that of lymphocyte homing, and suggested that chemokines and their receptors (CXCR4, CCR7 and CCR10) have a critical role in determining the metastatic destination of tumour cells [13]. The gene discussed is CXCR4; the disease is neoplasm.