BNIP3 and Familial prostate cancer: Although there is also a previous report suggesting that BNIP3 transcriptionally represses apoptosis-inducing factor (AIF) so that the miR-145-mediated down-regulation of BNIP3 consequently results in the up-regulation of AIF and subsequent death of prostate cancer cells10, care must be taken in interpreting such results since there are numerous oncogenic genes, as well as related signaling pathways, that have been confirmed as targets of miR-14511.