Melanocyte-specific proteins, shown to have a major role in differentiation, such as tyrosinase (TYR), tyrosinase-related protein 1 (TRP1) and 2 (TRP2), MART-1/Melan A and Pmel17/gp100, are also expressed in human melanoma cell lines and were recognized by T lymphocytes of patients with melanoma and are involved in tumor regression [22]. This evidence concerns the gene TYR and melanoma.