In this system, 49 credits were assigned to poor pathological grading, 33 to reduced expression of TGFBR2, 45 to over-expression of TGF-β, 32 to over-expression of MAPK, 100 to over-expression of pin1, 50 to over-expression in tumor tissue and 22 to reduced expression of TGF-β in normal mucosa. Here, PIN1 is linked to neoplasm.