In conclusion, this scoring system based on ANN model have identified reduced expression of TGFBR2, over-expression of TGF-β, MAPK, pin1, β-catenin in tumor tissue and reduced expression of TGF-β in normal mucosa as significant risk predictors for 10-year survival outcome in stage II A colon cancer patients after radical surgery. This evidence concerns the gene TGFBR2 and malignant colon neoplasm.