However, tumor Ags, including purified and recombinant subunit of tumor Ags, are usually poorly immunogenic for T and B cell activation, because Ag presenting cells (APCs), such as dendritic cells (DCs) and macrophages, present low levels of tumor antigens through MHC molecules and express low levels of co-stimulatory molecules [3, 4]. This evidence concerns the gene HLA-C and neoplasm.