These survival curves are reminiscent of a recent study of 1678 independent human breast cancer samples indicating that a GRHL2-mediated gene-set pair can “effectively stratify patients showing significant differences in metastasis-free survival”[39], and are congruent with reports indicating that higher levels of GRHL2 correlate with shorter RFS in breast cancer patients [40], and with lower OS and RFS in colorectal cancer patients [41]. Here, GRHL2 is linked to colorectal cancer.