HAVCR2 and cancer: For TIM-3 +4259T/G polymorphism, subjects carrying TG genotype or G allele had a significantly increased risk of overall cancer compared with those carrying the TT genotype or T allele, respectively (TG vs. TT: OR = 2.21, 95%CI: 1.44-3.38, Pz < 0.01; G vs. T: OR = 2.14, 95%CI: 1.41-3.26, Pz < 0.01) (Figure 2).