For TIM-3 −1516G/T polymorphism, subjects carrying GT genotype or T allele had a significantly increased risk of overall cancer compared with those carrying the GG genotype or G allele, respectively (GT vs. GG: OR = 1.99, 95%CI: 1.50-2.64, Pz < 0.01; T vs. G: OR = 1.95, 95%CI: 1.48-2.58, Pz < 0.01) (Figure S2). This evidence concerns the gene HAVCR2 and cancer.