TIM-3 −1516G/T polymorphism was associated with an increased risk of digestive system cancer (GT vs. GG: OR = 1.77, 95%CI: 1.08-2.91, Pz = 0.02; T vs. G: OR = 1.75, 95%CI: 1.08-2.85, Pz = 0.02) and other cancer (GT vs. GG: OR = 2.11, 95%CI: 1.26-3.56, Pz = 0.01; T vs. G: OR = 2.07, 95%CI: 1.25-3.44, Pz = 0.01). The gene discussed is HAVCR2; the disease is digestive system cancer.