HAVCR2 and cancer: In subgroup analyses based on cancer system, we found that TIM-3 −1516G/T polymorphism was only associated with an increased risk of digestive system cancer (GT vs. GG: OR = 1.75, 95%CI: 1.04-2.92, Pz = 0.03; TT+GT vs. GG: OR = 1.79, 95%CI: 1.05-3.05, Pz = 0.03; T vs. G: OR = 1.77, 95%CI: 1.05-2.96, Pz = 0.03).