DNER and cancer: Finally, it is intriguing that differentially increased expression of only three BET proteins could shift epigenetically regulated transcriptional networks in different cell types to reduce insulin production in β-cells [30,48], attenuate adipogenesis in pre-adipocytes [30], increase inflammatory cytokine production in macrophages [32,35] and promote cell cycle progression in diverse cancer cell types [17–19;23–25].