Furthermore, it was revealed that the siRNA induced HMGA1 could lead to the downregulation of Snail and upregulation of E-cadherin in both mRNA or protein levels in SW579 cells (Fig. 4c), resulting in the decrease of invasive abilities of thyroid cancer SW579 cells (Fig. 4d, P < 0.01). Here, HMGA1 is linked to thyroid cancer.