Our results show higher levels of IFN-γ in patients with DHF than DF.However, the proinflammatory cytokines IL-12p70, TNF-α, and IL-6 were found to beelevated in DHF in relation to those in DF, but only in patients infected with DENV2.For patients infected with DENV1, the TNF-α, IL-12p70, and IL-6 levels were higher in DFthan in DHF patients. This evidence concerns the gene IFNG and Dengue hemorrhagic fever.