Albanidou-Farmaki, et al.3(2005) stated that 34 out of 48 patients with recurrent minor aphthous ulcerations tested positive for H. pylori. He detected the assessed protein antibodies IgG, IgA and anti-CagA in the serum of 59 patients and in the saliva of 24 patients. Here, S100A8 is linked to canker sore.