The finding that EGFR mutations are more common in non-COPD lung cancer patients might indicate that lung cancer development is dependent on activating EGFR mutations in non-COPD patients.Chronic pulmonary diseases, such as severe asthma and COPD, cause an increased activation of the epithelial growth factor receptor (EGFR)[12, 40]. Here, EGFR is linked to chronic obstructive pulmonary disease.