KRAS and chronic obstructive pulmonary disease: Putting the variables (sex, age, smoking and COPD) in a logistic regression model confirmed the significant association between KRAS hotspot mutations with female sex (HR 2.61; 95% CI: 1.56–4.39; p<0.001) and smoking (HR 4.10; 95% CI: 1.14–14.79; p = 0.03) (Table 2).