TRIM63 and infection: Remarkably, TAK1 was phosphorylated strongly in HT-29 cells, but no phosphorylated TAK1 was detected throughout the infection in RD cells (Fig 2C and 2D), indicating that unlike in RD cells, both IRF and NFκB signaling pathways from TLR remained intact and activated in EV71-infected HT-29 cells (Wang et al., 2015).