As shown in Fig 3, OVA increased the production of TNF-α and IL-8, while the hydrolysates of LYS and OM with pepsin reduced the secretion of TNF-α; and those of OVA, LYS and OM with pepsin, and LYS alcalase, reduced the secretion of IL-8 (Fig 3a and 3b). The gene discussed is TNF; the disease is ocular melanoma.