Using data from the Framingham Heart Study, Dallmeier and others [26] recently showed that while intercellular adhesion molecule 1 (ICAM-1) concentration in serum is increased in individuals who eventually develop T2D, this association does not hold after accounting for other clinical covariates commonly used to predict T2D (e.g. age, sex, cohort, body mass index, fasting glucose, systolic blood pressure, high-density lipoprotein cholesterol, triglycerides, and smoking). This evidence concerns the gene ICAM1 and type 2 diabetes mellitus.