This is partly attributable to the endocrine role of the adipose tissue since reversion of the adiponectin:leptin ratio correlates with both insulin resistance and endothelial dysfunction.[23, 24] It has also been argued that decreased nitric oxide availability observed in a state of insulin resistance has been correlated with vascular cellular adhesion molecule-1 (VCAM-1) levels.[25]. The gene discussed is ADIPOQ; the disease is Insulin resistance.