Data for this study come from the San Antonio Family Heart Study (SAFHS) which enrolled participants from large and extended Mexican American families.[32–34] Using these data, we tested the hypothesis that circulating levels of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) are independently and additively predictive of future T2D. Here, ICAM1 is linked to type 2 diabetes mellitus.