In eight sporadic cases, we detected eight heterozygous rare sequence variants in six macular degeneration genes (CFH; FBLN1, OMIM 135820; FBLN3/EFEMP1, OMIM 601548; FBLN5, OMIM 604580; HMCN1, OMIM 608548; FBN2, OMIM 612570) (Table 1). The gene discussed is FBLN5; the disease is macular degeneration.