In addition, we found heterozygous rare sequence variants (MAF ≤0.01) in several extracellular matrix (ECM) genes, which include FBLN1, FBLN3/EFEMP1, FBLN5, FBLN6/HMCN1, FBN2, and COL15A1, in sporadic cases and families with the CD subtype of AMD by WES (Tables 1 and 2). The gene discussed is FBLN1; the disease is age-related macular degeneration.