Whereas FAL1 acts in trans on PRC1, ANRIL, a lncRNA transcribed from the INK4B-ARF-INK4A tumor suppressor locus, acts in cis. The ANRIL transcript was discovered in a family with inherited melanoma-neural system tumors and assumed to play a role in tumorigenesis [58]. This evidence concerns the gene CDKN2B-AS1 and melanoma.