We were particularly interested to test whether the presence of an intact IFNγ signaling pathway in A129 mice plays a role in the limited vascular leakage seen in this ADE model, compared to the ADE model in AG129 mice for which we previously reported extensive vascular permeability as the primary cause of morbidity for the infected mice that have acquired maternally transferred antibodies [31]. Here, IFNG is linked to acute disseminated encephalomyelitis.