At the early infection time point of day 2 p.i., only two cytokines, namely Granulocyte-colony stimulating factor (G-CSF) and monokine induced by IFN-γ (MIG), were significantly reduced in DENV2-infected mice born to DENV1-immune mothers compared to DENV2-infected mice born to naïve mothers (average values of 2026.72 pg/ml vs 7080.75pg/ml for G-CSF and 128.75pg/ml vs 395.42pg/ml for MIG) at day 4 p.i. when clinical symptoms were observed, a greater number of cytokines became differentially expressed. This evidence concerns the gene IFNG and infection.