In the present meta-analysis, we did not find that COX-2 inhibitors for treating NSCLC could expand the risk of thrombosis or embolism (RR = 1.23; 95% CI: 0.71, 2.14) and the risk of cardiac ischemia (RR = 2.35; 95% CI: 0.61, 9.0). The gene discussed is PTGS2; the disease is myocardial ischemia.