The cardiovascular events including ischemic heart disease and myocardial infarction, are associated with the vascular endothelial dysfunction, and increased circulating levels of inflammatory cytokines, such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α), which may be raised by the modifiable environmental factors [6]. The gene discussed is TNF; the disease is myocardial infarction.