FOXO1 and Increased total eosinophil count: In order to address whether FoxO1 regulated a pro-asthmatic macrophage phenotype and the type 2 immune response, we utilized genetic and pharmacological approaches, including development of macrophage-specific FoxO1-deficient and -overexpressing mice that were test in the DRA model which exhibits impressive asthmatic airway changes [8, 33] including peribronchial and alveolar eosinophilia [8, 34].