Recent studies revealed that CISD2-BCL2 complex may negatively modulate the BECN1 autophagy-initiating complex via PIK3C3 and regulate endoplasmic reticulum (ER) Ca2+ homeostasis via ER inositol 1,4,5-triphosphate receptor (ITPR/IP3R) and contributes to tumor carcinogenesis and progression in LSCC [28]. The gene discussed is BCL2; the disease is neoplasm.