Even though its basic premise is that present and future events are inseparably intertwined, therapeutic action-at-a-distance is less esoteric and “spooky” (as Einstein called quantum entanglement [80]) than its counterpart in physics: through Newton's 3rd law, the action of chemotherapy elicits a reaction, a pleiotropic adaptive response affecting DNA replication and repair, drug sensitivity, and P-glycoprotein-mediated (Pgp, MDR1, ABCB1) drug efflux that renders the tumor either more sensitive or more resistant to additional therapies. The gene discussed is ABCB1; the disease is neoplasm.