FGF2 induces IL-6 release in human pancreatic periacinar myofibroblasts. Overexpression of FGF2 (24-kDa isoform) upregulates IL-6 transcription in NIH-3T3 cells. FGF2 is downstream effector of IL-6-induced angiogenic activity in cancer cells. This evidence concerns the gene FGF2 and cancer.