In addition, equivalent levels of IL-2 and a similar induction of early activation markers CD25 and CD69 were found in control activated T cells and those co-cultured with tumor-MDSC (Figure 2B-2C), demonstrating that MDSC impaired the progression of CD8+ T cells into effector populations, without altering TCR-related signaling or early activation processes. This evidence concerns the gene CD8A and neoplasm.