Thirty-seven (37 = 58.7%) of these DMRs associated with genes, but only 6 (16.2%) of those have been implicated in either colitis (PTPRF, ELTD1, and GDNF) or CRC (PTPRF, ELTD1, PDX1, CCK, and AGPAT1). This evidence concerns the gene ADGRL4 and colitis.