Eleven (11 = 57.9%) of these 19 genes have already been implicated in either colitis (SHANK2, SLC9A3, TAGAP, and PON1) or CRC (KCNN3, SULT2B1, SP5, TRIM15, MLL3, CREB5, and SULF1). This evidence concerns the gene SULF1 and colorectal carcinoma.