Eleven (11 = 57.9%) of these 19 genes have already been implicated in either colitis (SHANK2, SLC9A3, TAGAP, and PON1) or CRC (KCNN3, SULT2B1, SP5, TRIM15, MLL3, CREB5, and SULF1). The gene discussed is KMT2C; the disease is colorectal carcinoma.