Eleven (11 = 57.9%) of these 19 genes have already been implicated in either colitis (SHANK2, SLC9A3, TAGAP, and PON1) or CRC (KCNN3, SULT2B1, SP5, TRIM15, MLL3, CREB5, and SULF1). Here, KMT2C is linked to colitis.