In one case using the diet-induced obesity/metabolic syndrome rat model [63], supplementary data provided evidence that GB88, a biased PAR2 antagonist, treatment blunted the effect of HCHF-feeding on several indices of cardiac function and the interstitial collagen content in the left ventricular myocardium; however, cardiac output was not different between controls and treatments. The gene discussed is F2RL1; the disease is obesity disorder.