In this prospective study of patients with MDR-TB, (half of them with primary drug-resistance and type 2 diabetes, without HIV infection) using the low-dose ACTH stimulation test, we found two cases (4.2%) of adrenal insufficiency using the 500 nmol/L cutoff cortisol value and 4 cases (8.3%) using the 550 nmol/L criterion. This evidence concerns the gene POMC and HIV infectious disease.