EWS-Fli1 has also a transcriptional repressor role [21], as it is able to directly inhibit the expression of some tumor suppressor genes such as p21 [22], p57kip [10], TGF-βRII [11, 21, 23] and IGFBP3 [24], often associated with development, differentiation and cell communication. The gene discussed is FLI1; the disease is neoplasm.