In addition, we have also demonstrated that the JQ1(+)-mediated BET bromodomain inhibition has a consequent downstream effect on the ERK1/2 signaling, one of the pathways that EWS-Fli1 normally activates and which contributes to the preservation of the Ewing Sarcoma malignant features [49]. The gene discussed is MAPK3; the disease is Ewing sarcoma.