DNER and Ewing sarcoma: To evaluate the therapeutic potential of BET bromodomain inhibition in Ewing Sarcoma, we used the JQ1(+) active form of the soluble pharmacological inhibitor JQ1, a thienotriazolo-1, 4-diazepine that binds selectively to the acetyl-lysine-binding pocket of the BET bromodomain protein (Figure 1C) [44].