In contrast, H2AX levels dropped in both compartments (Fig 4A and B), in a correlative way (Fig 4C), in HER2 and TN carcinomas, which have been characterized by chronic oxidative stress (Finak et al, 2008; Martinez‐Outschoorn et al, 2010; Toullec et al, 2010; Balliet et al, 2011; Parri & Chiarugi, 2013). The gene discussed is ERBB2; the disease is carcinoma.