As junD‐ or Nfe2l2‐deficient fibroblasts mimic features of carcinoma‐associated fibroblasts (CAFs) due to ROS increase (Toullec et al, 2010; Artaud‐Macari et al, 2013), we first tested whether H2AX downregulation could be observed in CAFs from invasive breast carcinomas. This evidence concerns the gene NFE2L2 and carcinoma.