KDR and neoplasm: Immunoblotting of lysates from individual tumours showed that the pY1173/VEGFR2 ratio was significantly higher at D12 in tumours from WT mice compared with Vegfr2Y949F/Y949F mice (Fig. 6c; lower part shows representative immunoblot), correlating with the VEGFA signalling data from lung lysates (Fig. 6a).