The restriction in VEGFR2 signalling in tumours from the Vegfr2Y949F/Y949F mice at D12 may involve dephosphorylation of VEGFR2 by VEPTP, as we found increased levels of VEGFR2/VEPTP complexes in the Y949F condition (Fig. 6e; lower part shows representative blot). The gene discussed is KDR; the disease is neoplasm.