The findings of our previous study showed that CPIT consisting of induction treatment with natural (n)-IFN-β and subsequent maintenance treatment with n-IFN-α could prevent viral breakthrough and achieved RVR and EVR, and induced restoration of innate immune responses, as shown by the significant decrease of CXCL-10, CXCL-8 and CCL-4, and the significant increase of IL-12 and IL-15 in CHC [20]. This evidence concerns the gene IFNA1 and cryohydrocytosis.