We previously reported that a difficult-to-cure CHC patient with genotype 1b, a high viral load, null response to previous IFN treatments, and advanced hepatic fibrosis was treated by IT with n-IFN-β followed by triple therapy with simeprevir with PR, which resulted in SVR and a sustained biochemical response (SBR) [23]. This evidence concerns the gene IFNB1 and Hepatic fibrosis.