Viral suppression linked to the restoration of innate immune responses with IT with n-IFN-β followed by PI plus Peg-IFN-α-2b and RBV was tolerated well without discontinuation, overcame viral breakthrough and induced persistent viral clearance, leading to an enhanced early virologic response, and resulted in SVR 12 and SBR in difficult-to-treat CHC patients with genotype 1b and high viral loads. Here, IFNB1 is linked to cryohydrocytosis.