More recently, it has been found that, by investigating the interaction between hypertension and AD in cerebrovascular function, the administration of AngII or deoxycorticosterone acetate (DOCA)-salt to induce hypertension further aggravates the cerebrovascular effects of Aβ in transgenic TgSwDI mice with elevated brain levels of Aβ [83]. The gene discussed is AGT; the disease is hypertensive disorder.