Another association at 2q35 defined by rs2382817 has previously been shown to influence IBD risk (CRC meta P = 1.02 × 10−5), which is also intronic to PNKD and TMBIM1, and is in strong LD with rs992157 (r2 = 0.90, D′ = 0.96). This evidence concerns the gene TMBIM1 and colorectal carcinoma.