Using data on microsatellite instability (MSI) status from the FIN (n = 1146), COIN (n = 1239) and NSCCG replication (n = 1282) series, together with information on KRAS and BRAF mutation status in tumours in COIN, we explored the possibility that the association at rs992157 is restricted to a specific molecular subtype of CRC (Supplementary Material, Table S3). The gene discussed is BRAF; the disease is neoplasm.