B3GNT2 and colorectal carcinoma: Together, mutations in these genes were detected in 5 of the 31 CRC cases tested, with 3 mutations in B3GNT2 (R6X, P186T, D247H), 2 mutations in ST6GALNAC2 (D43H, R115W), and 1 mutation in B4GALT2 (A146V) accompanied by a loss of the wild-type allele (Table 2, Fig. 3b).