In particular, reduced expression of Core 3 synthase, an enzyme involved in the initial step of Core 3 biosynthesis, has been observed frequently in colon, gastric, and pancreatic ductal adenocarcinomas, with loss of Core 3 synthase expression highly correlating with the grade of colon neoplasia in familial adenomatous polyposis patients28, 29. The gene discussed is B3GNT6; the disease is pancreatic ductal adenocarcinoma.