Our previous studies have showed that central salusin-β is involved in sympathetic activation and hypertension in hypertensive rats11, 12, 13, and peripheral salusin-β contributes to vascular remodeling associated with hypertension by promoting human VSMC proliferation via cAMP-PKA-EGFR-CREB/ERK pathway and vascular fibrosis via TGF-β1-Smad pathway14. The gene discussed is CREB1; the disease is hypertensive disorder.