AS3MT and schizophrenia: This is consistent with the risk allele of ch10_104957618_I conferring susceptibility to schizophrenia through effects on a different gene, such as NT5C2. However, the risk allele of ch10_104957618_I appears insufficient to fully counteract the increased expression of AS3MT associated with the risk allele of rs11191419, with allele ratios in cDNA from ch10_104957618_I heterozygotes remaining significantly higher than the genomic 1:1 ratio in most assayed tissues.