Genome-wide association studies in humans have also highlighted the influence of variations in the FADS1 and FADS2 gene cluster on glucose and lipid metabolisms, such as total cholesterol [15] and LDL-cholesterol, and disease conditions such as metabolic syndrome, myocardial infarction, and dyslipidemia [16, 17]. However, few studies have specifically focused on the association between genetic polymorphisms in the FADS gene cluster and the risk of T2D&CAD. This evidence concerns the gene FADS2 and metabolic syndrome.