APOB and coronary artery disorder: Clinical studies [28, 29] have shown that lipid-lowering therapy, such as statins, plays an extremely important role in preventing and treating CAD, and statins can competitively inhibit 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and can reduce hepatic cholesterol synthesis, circulating LDL-cholesterol levels, and other apolipoprotein B-containing lipoproteins [30, 31].