Metformin therapy showed no effect on tumor size.With using Allred scoring (0-8)-- Mean change in pAMPK score:Metformin- 5.18 to 6.45Control arm- 5.64 to 6.00- Change in pAKT staining score:Metformin- 5.91 to 5.00Control arm- 4.91 to 5.18- Mean change in Ki67 staining:Metformin- decrease by 3.4%Control arm- stable- Caspase-3 staining:Metformin- reduced by 0.29%Control arm- no significant change. Here, CASP3 is linked to neoplasm.