E2F4 and neoplasm: Of these lncRNAs, for example, the upregulated E2F4 antisense in CRC was induced by WNT/beta-catenin signaling, which resulted in E2F4 downregualtion [19]; LOC285194/TUSC7 was found with lower expression in tumor and functioned as TP53-regulated tumor suppressor that inhibited cell growth through the repression of miR-211 [20, 21].