Experimental studies in the remnant kidney model have shown that normalization of both glomerular and systemic hypertension with an angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker, compared to normalization of systemic hypertension alone using alternative antihypertensive agents, is associated with attenuation of proteinuria and FSGS [13, 14]. The gene discussed is ACE; the disease is Hypertension.