For instance, although mTORC1 promotes lipogenesis in the liver cells through sterol regulatory element binding protein (SREBP) activation, this effect was abolished in mice with liver-specific depletion of TSC1 and also resulted in insulin resistance, due to the simultaneous inhibition of Akt/PKB in this tissue [22, 26, 46]. The gene discussed is AKT1; the disease is Insulin resistance.